|
KMID : 0061119820100000049
|
|
Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.49 ~ p.49
|
|
|
Oral Desensitization on DNCB Presensitized Guinea Pigs
|
|
Choi, Guk-Joo
Choo, Eun-Hee/Kim, Tae-Yoon/Kim, Jin-Wou/Houh, Won
|
|
|
Abstract
|
|
|
Repeated feeding of dinitrochlorobenzene (DNCB) in parenterally pre primed guinea pigs resulted in specific tolerogenic effect. In this experiment, the animals were initially pre-primed to DNCB, each given daily feeding of 3 mg DNCB dissolved in olive oil for 6 days, and subsequently challenged with DNCB at three different intervals. The feeding resulted in a partial suppression of contact sensitivity reaction which lasted for approximately ´4 weeks.
The antigen specificity of oral desensitization in the pre-primed guinea pigs was also demonstrated. In the trinitrochlorobenzene (TNCB) ;pre-primed animals, DNCB feeding had no effect on the development of TNCB contact sensitivity reaction, but induced specific tolerance to DNCB contact sensitivity.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|